Transplacental transfer of genotoxins and transplacental carcinogenesis.
نویسندگان
چکیده
منابع مشابه
Transplacental transfer of genotoxins and transplacental carcinogenesis.
A number of chemical compounds induce cancer in the offspring of animals treated with these compounds. The fetus is sensitive to the toxic and teratogenic effects of chemicals in the early embryonic stages, whereas it is sensitive to carcinogenic effects during late fetal stages. Carcinogens may be direct acting or may require metabolic oxidation such as those in tobacco smoke. Activation can o...
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Our work has focused on the carcinogenic effects of in utero arsenic exposure in mice. Our data show that a short period of maternal exposure to inorganic arsenic in the drinking water is an effective, multi-tissue carcinogen in the adult offspring. These studies have been reproduced in three temporally separate studies using two different mouse strains. In these studies pregnant mice were trea...
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Transplacental transfer of genotoxic material has been determined by measuring the polycyclic aromatic hydrocarbon-albumin adduct level in serum isolated from the mother and the umbilical cord blood using a competitive enzyme-linked immunoadsorbent assay (ELISA) and the antibody (8E11( against benzo[a]pyrene (B[a]P) tetrols. Smoking women (median = 5.54 fmol B[a]P eq/micrograms albumin; n = 21 ...
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The carcinogenicity of safrole following transplacental ex posure of the mouse fetus and exposure of the neonatal mouse via the mother's milk was investigated in C57BL/6J x CSHeB/ FeJ F, (hereafter called B6C3F,) mice by intragastric admin istration of the agent to pregnant and lactating C57BL/6J females. Safrole (120 ftg/g body weight per treatment) was administered to (a) pregnant mice (4 tim...
متن کاملTransplacental transfer and metabolism of buprenorphine.
Information on the direct and indirect effects of buprenorphine (BUP) on the fetus is essential for determining its potential for treatment of the pregnant opiate addict. The goal of this investigation is to determine the transplacental transfer of BUP to the fetal circulation, its metabolism, and effects on the tissue. The technique of dual perfusion of placental lobule is used. The range of B...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1993
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.93101s233